Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke
Xiaoqian Shan, Yongyin Luo, Jun Chang, Jingjing Song, Nan Hao, Lan Zhao
Abstract
modulation of the immune response is an additional treatment option for IS. Intriguingly, MSC-Exos mediates the inflammatory immune response following IS by modulating the central nervous system, the peripheral immune system, and immunomodulatory molecules, thereby promoting neurofunctional recovery after stroke. Thus, this paper reviews the role, potential mechanisms, and therapeutic potential of MSC-Exos in post-IS inflammation in order to identify new research targets.
Topics & Concepts
Mesenchymal stem cellMedicineContext (archaeology)MicrovesiclesStroke (engine)TransplantationInflammationCell therapyImmune systemStem-cell therapyStem cellDiseaseImmunologyBioinformaticsNeurosciencePathologyInternal medicinemicroRNABiologyCell biologyEngineeringPaleontologyMechanical engineeringGeneBiochemistryExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsMesenchymal stem cell research