In vitro and in vivo models for monkeypox
Rafael Borges Rosa, Emilene Ferreira de Castro, Murilo Vieira da Silva, Denise Caroline Paiva Ferreira, Ana Carolina Gomes Jardim, Igor Andrade Santos, Mikaela dos Santos Marinho, Flávia Batista Ferreira França, Lindomar Pena
Abstract
models are being characterized to meet the growing demand for new studies related to MPXV. In this review, we summarize the main MPXV models that have already been developed and discuss how they can contribute to advance the understanding of its pathogenesis, replication, and transmission, as well as identifying antivirals to treat infected patients.
Topics & Concepts
MonkeypoxPandemicCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyBiologyMedicineInfectious disease (medical specialty)OutbreakDiseasePathologyGeneVacciniaRecombinant DNABiochemistryPoxvirus research and outbreaksPlant Virus Research StudiesHerpesvirus Infections and Treatments