Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
Xiang Sun, Tobias Ritter
Abstract
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late-stage modification.
Topics & Concepts
DecarboxylationScope (computer science)Substrate (aquarium)ChemistryCombinatorial chemistryFunctional groupSmall moleculeOrganic chemistryComputer scienceBiologyCatalysisBiochemistryEcologyPolymerProgramming languageFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques