Electrophotocatalytic Hydroxymethylation of Azaarenes with Methanol
Beatriz Quevedo-Flores, Irene Bosque, José C. González‐Gómez
Abstract
The merging of electrochemistry and photocatalysis allowed the required selectivity for the hydroxymethylation of functionalized azaarenes with methanol, including bioactive substrates. The two electrophotocatalytic protocols developed in this work address this transformation, using nontoxic and readily available reagents under mild reaction conditions with electricity as the only "sacrificial oxidant".
Topics & Concepts
ChemistryMethanolReagentPhotocatalysisSelectivityCombinatorial chemistryElectrochemistryOrganic chemistryCatalysisPhysical chemistryElectrodeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques