Mechanochemical arylative detrifluoromethylation of trifluoromethylarenes
Satenik Mkrtchyan, Mohanad Shkoor, Sehrish Sarfaraz, Khurshid Ayub, Viktor O. Iaroshenko
Abstract
A mechanochemically induced, nickel-catalyzed one-pot multicomponent protocol for a direct arylative detrifluoromethylation of ArCF 3 is described. This reaction represents the first example of C–C coupling with CF 3 as a leaving group.
Topics & Concepts
CyanationChemistrySurface modificationCombinatorial chemistryInertMoleculeStoichiometryCatalysisOrganic chemistryPhysical chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCarbon dioxide utilization in catalysis