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Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews, Connie P.M. Duong, Vancheswaran Gopalakrishnan, Valerio Iebba, Wei-Shen Chen, Lisa Derosa, M.A. Wadud Khan, Alexandria P. Cogdill, Michael G. White, Matthew C. Wong, Gladys Ferrere, Aurélie Fluckiger, María Paula Roberti, Paule Opolon, Maryam Tidjani Alou, Satoru Yonekura, Whijae Roh, Christine N. Spencer, Irina Fernandez Curbelo, Luis M. Vence, Alexandre Reuben, Sarah B. Johnson, Reetakshi Arora, Golnaz Morad, Matthew Lastrapes, Erez N. Baruch, Latasha Little, Curtis Gumbs, Zachary A. Cooper, Peter A. Prieto, Khalida Wani, Alexander J. Lazar, Michael T. Tetzlaff, Courtney W. Hudgens, Margaret K. Callahan, Matthew Adamow, Michael A. Postow, Charlotte E. Ariyan, Pierre-Olivier Gaudreau, Luigi Nezi, Didier Raoult, Catalin Mihalcioiu, Arielle Elkrief, Rossanna C. Pezo, Lauren E. Haydu, Julie M. Simon, Hussein A. Tawbi, Jennifer L. McQuade, Patrick Hwu, Wen-Jen Hwu, Rodabe N. Amaria, Elizabeth M. Burton, Scott E. Woodman, Stephanie S. Watowich, Adi Diab, Sapna P. Patel, Isabella C. Glitza, Michael K.K. Wong, Li Zhao, Jianhua Zhang, Nadim J. Ajami, Joseph F. Petrosino, Robert R. Jenq, Michael A. Davies, Jeffrey E. Gershenwald, P. Andrew Futreal, Padmanee Sharma, James P. Allison, Bertrand Routy, Laurence Zitvogel, Jennifer A. Wargo

2021Nature Medicine418 citationsDOIOpen Access PDF

Topics & Concepts

CTLA-4BlockadeGut floraToxicityMedicineImmunologyBiologyInternal medicineImmune systemReceptorT cellGut microbiota and healthTryptophan and brain disordersMicroscopic Colitis
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade | Litcius