Photoredox/Copper Dual-Catalyzed Phosphorothiolation of Propargylic Derivatives for the Switchable Synthesis of <i>S</i>-Alkyl, <i>S</i>-Vinyl and <i>S</i>-Allenyl Phosphorothioates
Shanshan Shi, Hu Chen, Shiwei Yang, Hua‐Ze Dong, Jinmiao Zhu, Bin Zheng, Xiaohong Wang, Zhaoyang Liang, Hong‐Yu Ren, Yuzhen Gao
Abstract
Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides a general, mild and versatile procedure to synthesize a variety of synthetically useful S -alkyl, S -vinyl and S -allenyl phosphorothioates selectively from the same set of simple starting materials.
Topics & Concepts
ChemistryAlkylCopperCatalysisCombinatorial chemistryDual (grammatical number)Photoredox catalysisDual roleOrganic chemistryPhotocatalysisArtLiteratureSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions