Identifying hot spots of inhibitor-CDK2 bindings by computational alanine scanning
Juan Zhao, Baohua Yin, Haibo Sun, Laixue Pang, Jianzhong Chen
Topics & Concepts
Alanine scanningCyclin-dependent kinase 2SpotsHot spot (computer programming)ChemistryCombinatorial chemistryMaterials scienceKinaseBiological systemBiophysicsNanotechnologyComputer scienceBiochemistryProtein kinase ABiologyGeneMutationOperating systemPhysical chemistryMutagenesisProtein Structure and DynamicsEnzyme Structure and FunctionComputational Drug Discovery Methods