Litcius/Paper detail

In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy

Lei Peng, Paul Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J. Park, Ryan D. Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z. Lam, Lupeng Ye, Sidi Chen

2024Nature Biotechnology52 citationsDOIOpen Access PDF

Topics & Concepts

Chimeric antigen receptorBiologyInterleukin 12NK-92Lymphokine-activated killer cellDegranulationInterleukin 21Natural killer cellCancer researchImmunotherapyCancer immunotherapyJanus kinase 3CytotoxicityImmunologyCytotoxic T cellAntigenReceptorIn vitroImmune systemCD8BiochemistryImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology