In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy
Lei Peng, Paul Renauer, Giacomo Sferruzza, Luojia Yang, Yongji Zou, Zhenghao Fang, Jonathan J. Park, Ryan D. Chow, Yueqi Zhang, Qianqian Lin, Meizhu Bai, Angelica Sanchez, Yongzhan Zhang, Stanley Z. Lam, Lupeng Ye, Sidi Chen
Topics & Concepts
Chimeric antigen receptorBiologyInterleukin 12NK-92Lymphokine-activated killer cellDegranulationInterleukin 21Natural killer cellCancer researchImmunotherapyCancer immunotherapyJanus kinase 3CytotoxicityImmunologyCytotoxic T cellAntigenReceptorIn vitroImmune systemCD8BiochemistryImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology