Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
Xiangbo Yang, Zhijia Wang, Yuan Pei, Ning Song, Lei Xu, Bo Feng, Hanlin Wang, Xiaomin Luo, Xiaobei Hu, Xiaohui Qiu, Huijin Feng, Yaxi Yang, Yubo Zhou, Jia Li, Bing Zhou
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayProtein kinase BMAPK/ERK pathwayProteolysisProtein tyrosine phosphataseSmall moleculeProtein degradationComputational biologySignal transductionCell biologyCancer researchBiochemistryEnzymeBiologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways