Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
Gergana Popova, Marcus J.G.W. Ladds, Lars Johansson, Aljona Saleh, Johanna M. Larsson, Lars Sandberg, Sara Häggblad Sahlberg, Weixing Qian, Hjalmar Gullberg, Neeraj Garg, Anna‐Lena Gustavsson, Martin Haraldsson, David P. Lane, Ulrika Yngve, Sonia Laı́n
Abstract
as a favorable candidate for preclinical efficacy studies.
Topics & Concepts
Dihydroorotate dehydrogenasePyrimidine metabolismChemistryEnzymeBiochemistryUridinePyrimidineIn vitroViability assayPharmacologyBiologyRNAGenePurineBiochemical and Molecular ResearchAcute Lymphoblastic Leukemia researchHIV/AIDS drug development and treatment