Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters
Mingliang Han, Junjie Chen, Hui Xu, Zhi-Cong Huang, Wei Huang, Yuwen Liu, Xing Wang, Min Liu, Ziqiong Guo, Hui‐Xiong Dai
Abstract
-positions of the aromatic thioesters. By combining carboxyl-directed C-H functionalization and the classical Catellani reaction, our protocol allows for the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug molecules highlights the potential utility of the reaction.
Topics & Concepts
NorborneneArylChemistryPalladiumDecarboxylationCatalysisAlkylCombinatorial chemistrySurface modificationOrganic chemistryCarboxylic acidPolymerizationPolymerPhysical chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions