Oxime Ether Synthesis through O–H Functionalization of Oximes with Diazo Esters under Blue LED Irradiation
Qian Li, Bao‐Gui Cai, Lei Li, Jun Xuan
Abstract
A green and sustainable oxime ether formation method via the visible-light-promoted O-H functionalization of oximes with diazo esters is described. The reaction occurs under very mild conditions (catalyst- and additive-free) with a high yield and a high functional group tolerance. When the reaction was performed with a cyclic ether as the solvent (e.g., THF, 1,4-dioxane, tetrahydropyran, ect.), an interesting photochemical three-component reaction product was obtained in good yields.
Topics & Concepts
ChemistryOximeTetrahydropyranDiazoYield (engineering)EtherSurface modificationFunctional groupSolventCatalysisOrganic chemistryMedicinal chemistryRing (chemistry)Materials sciencePhysical chemistryPolymerMetallurgyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques