Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer
Deping Li, Wenwu Liu, Yaoguan Huang, Mingyue Liu, Caizhi Tian, Hongyuan Lu, Hui Jia, Zihua Xu, Huaiwei Ding, Qingchun Zhao
Topics & Concepts
ADMEIn vivoChemistryCell cycleIn vitroApoptosisCell growthPharmacologyIn silicoKinaseGrowth inhibitionCell cycle checkpointBiochemistryCancer researchBiologyGeneBiotechnologySynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and Biological Evaluation