Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis
Marcela Garzón-Tituaña, José Luis Sierra-Monzón, Laura Comas, Llipsy Santiago, Tatiana Khaliulina-Ushakova, Iratxe Uranga-Murillo, Ariel Ramírez-Labrada, Elena Tapia, Elena Morte-Romea, Sonia Algarate, Ludovic Couty, Eric Camerer, Phillip I. Bird, Cristina Seral, Pilar Luqué, José Ramón Paño‐Pardo, Eva M. Gálvez, Julián Pardo, Maykel Arias
Abstract
Our findings implicate GzmA as a key regulator of the inflammatory response during abdominal sepsis and provide solid evidences about its therapeutic potential for the treatment of this severe pathology.
Topics & Concepts
Granzyme AProinflammatory cytokineSepsisPeritonitisImmunologyMedicineSpleenInflammationGranzyme BInternal medicineImmune systemT cellVitamin C and Antioxidants ResearchPharmacological Effects of Natural CompoundsImmune Response and Inflammation