Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
Veronica Astro, Gustavo Ramírez-Calderón, Roberta Pennucci, Jonatan Caroli, Alfonso Saera-Vila, Kelly J. Cardona‐Londoño, Chiara Forastieri, Elisabetta Fiacco, Fatima Maksoud, Maryam Alowaysi, Elisa Sogne, Andrea Falqui, Federico Gonzãlez, Núria Montserrat, Elena Battaglioli, Andrea Mattevi, Antonio Adamo
Abstract
hESCs give rise to functional cardiac cells, displaying increased beating amplitude and frequency and enhanced expression of critical cardiogenic markers. Our findings prove the existence of a divergent scaffolding role of KDM1A splice variants, independent of their enzymatic activity, during hESC differentiation into cardiac cells.
Topics & Concepts
Alternative splicingBiologyCell biologyDemethylaseHistoneCancer researchGene isoformGeneticsGeneEpigenetics and DNA MethylationRNA Research and SplicingRNA modifications and cancer