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Quantum light-field microscopy for volumetric imaging with extreme depth of field

Yingwen Zhang, Duncan England, Antony Orth, Ebrahim Karimi, Benjamin Sussman

2024Physical Review Applied15 citationsDOIOpen Access PDF

Abstract

Light-field microscopy (LFM) extracts volumetric data from a specimen by simultaneously capturing the positional and angular information of light rays emanating from the sample. While conventional LFM requires a compromise between depth of field (DOF) and resolution, this work introduces a quantum approach to eliminate this compromise by harnessing position-momentum entanglement of photon pairs. Compared to conventional LFM at the same resolution, the quantum approach can yield up to tenfold improvement in DOF. This work illustrates the power of utilizing multidimensional entanglement in microscopy and hopefully will inspire further innovations in the field.

Topics & Concepts

Field (mathematics)Depth of fieldMicroscopyLight fieldOpticsDark field microscopyMaterials sciencePhysicsMathematicsPure mathematicsRandom lasers and scattering mediaAdvanced Fluorescence Microscopy TechniquesDigital Holography and Microscopy
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