Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds
Göran Schulz, Catherine Victoria, Andreas Kirschning, Eike Steinmann
Abstract
Covering: up to the beginning of 2020Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)CoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBiologyMedicineInfectious disease (medical specialty)DiseasePathologyOutbreakPhytochemical compounds biological activitiesCancer Mechanisms and TherapyPlant-derived Lignans Synthesis and Bioactivity