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Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells

Zhaoping Pan, Yi Chen, Haiying Pang, Xiaoyun Wang, Yuehua Zhang, Xin Xie, Gu He

2022European Journal of Medicinal Chemistry16 citationsDOIOpen Access PDF

Topics & Concepts

PI3K/AKT/mTOR pathwayChemistryHsp90Protein kinase BCell growthApoptosisHeat shock proteinCancer researchHsp90 inhibitorCancer cellPharmacologyCancerBiochemistryBiologyGeneticsGeneHeat shock proteins researchATP Synthase and ATPases ResearchComputational Drug Discovery Methods
Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells | Litcius