Enantioselective Construction of Oxindoles Bearing a Quaternary Carbon via Ni−Al Bimetal‐Catalyzed Formyl C−H Alkylation
Haorui Wang, Jiang‐Fei Li, Mengying Xu, Qi‐Lin Zhou, Weiwei Xu, Mengchun Ye
Abstract
Enantioselective transition metal-catalyzed C-H alkylation emerges as one of the most atom- and step-economical routes to chiral quaternary carbons, while big challenges still remain with acyl C-H alkylations. Herein, we use a Ni-Al bimetallic catalyst to facilitate a highly regioselective and highly enantioselective C-H alkylation of formamides with alkenes, constructing various oxindoles bearing a chiral quaternary carbon in up to 94 % yield and up to 95 % ee.
Topics & Concepts
BimetalEnantioselective synthesisAlkylationCatalysisChemistryQuaternary carbonBearing (navigation)QuaternaryOrganic chemistryBiologyComputer scienceArtificial intelligencePhysical chemistryPaleontologyCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms