Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity
Silvia Bona, Sabrina Alves Fernandes, Andréa Janz Moreira, Graziella Rodrigues, Elizângela Gonçalves Schemitt, Fábio Cangeri Di Naso, Cláudio Augusto Marroni, Norma Possa Marroni
Abstract
BACKGROUND: Melatonin (MLT) is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations, due to its action against free radicals. AIM: ) induced liver injury in rats in terms of oxidative stress, reticular stress, and cell damage. METHODS: wk). RESULTS: glucose-regulated protein 78 and activating transcription factor 6, as well as of heat shock factor 1 and heat shock protein 70. CONCLUSION: -induced liver injury, since it reduces oxidative stress, restores zinc levels, and modulates endoplasmic reticulum stress.
Topics & Concepts
Oxidative stressEndocrinologySuperoxide dismutaseMelatoninInternal medicineChemistryLipid peroxidationThiobarbituric acidAntioxidantEndoplasmic reticulumCarbon tetrachlorideMedicinePharmacologyBiochemistryOrganic chemistryLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and DiseaseGenomics, phytochemicals, and oxidative stress