Mechanisms involved in the anticancer effects of sinapic acid
Pandi Anandakumar, Vanitha Manickam Kalappan
Abstract
Abstract Background Cancer refers to a group of diseases characterized by the development of abnormal cells that divide uncontrollably and have the ability to infiltrate and destroy normal body tissue. Worldwide, it is the second most leading cause of death. Dietary intake of bioactive compounds from plant sources has been documented for their protective effect against different types of human ailments including cancer. Main body Sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) (SA) is a promising phytochemical, available in oil seeds, berries, spices, vegetables and cereals. SA has been well documented for its antibacterial, anti-peroxidative, anti-hyperglycemic, anticancer, hepatoprotective, reno-protective, anti-inflammatory, neuroprotective, immunomodulatory and anticancer effects. Nevertheless, the anticancer activity of SA has remained a challenge with regard to understanding its mechanism in health and diseases. Short conclusion This review is an effort to summarize the updated literature available about the mechanisms involved in the anticancer effects of SA in order to recommend this compound for further future investigations.