Selective loss of the GABA <sub>Aα1</sub> subunit from Purkinje cells is sufficient to induce a tremor phenotype
Angela K. Nietz, Chris Krook-Magnuson, Haruna Gutierrez, Julia Klein, Clarke Sauve, Isaac Hoff, Zoé Christenson Wick, Esther Krook‐Magnuson
Abstract
Animals with a global knockout of the GABA Aα1 subunit show a tremor phenotype reminiscent of essential tremor. Here we show that selective knockout of GABA Aα1 from Purkinje cells is sufficient to produce a tremor phenotype, although this tremor is less severe than seen in animals with a global knockout. These findings illustrate that the cerebellum can play a key role in the genesis of the observed tremor phenotype.
Topics & Concepts
CerebellumGABAA receptorKnockout mousePurkinje cellPhenotypeNeuroscienceBiologyProtein subunitInhibitory postsynaptic potentialGeneticsReceptorGeneNeurological disorders and treatmentsPhotoreceptor and optogenetics researchNeuroscience and Neuropharmacology Research