The energetic landscape of CH–π interactions in protein–carbohydrate binding
Allison M. Keys, David W. Kastner, Laura L. Kiessling, Heather J. Kulik
Abstract
Over hundreds of PDB structures of protein–sugar complexes, our work demonstrates the prevalence of CH–π stacking interactions, and energetic analysis shows that numerous orientations allow for highly favorable interaction strengths.
Topics & Concepts
CarbohydrateChemistryBiophysicsBiochemistryBiologyProtein Structure and DynamicsEnzyme Structure and FunctionBiochemical effects in animals