Therapeutic ultrasound combined with microbubbles improves atherosclerotic plaque stability by selectively destroying the intraplaque neovasculature
Xinzhong Li, Shengcun Guo, Tong Xu, Xiang He, Yili Sun, Xiaoqiang Chen, Shiping Cao, Xiaoyun Si, Wangjun Liao, Yulin Liao, Yuan Han, Jianping Bin
Abstract
: TUS treatment at 3.0 MPa selectively depleted plaque neovessels and improved the stability of vulnerable plaques through a reduction in erythrocyte extravasation and inflammatory mediator influx, with no significant effect on normal tissue.
Topics & Concepts
MicrobubblesNeovascularizationUltrasoundMedicineMechanical indexAtheromaMicrovesselPathologyFibrous capImmunohistochemistryAngiogenesisInternal medicineRadiologyUltrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic ImagingAngiogenesis and VEGF in Cancer