Some thermodynamic effects of varying nonpolar surfaces in protein-ligand interactions
David L. Cramer, Bowen Cheng, Jianhua Tian, John H. Clements, Rachel M. Wypych, Stephen F. Martin
Topics & Concepts
ChemistryIsothermal titration calorimetryAffinitiesEnthalpyBinding affinitiesSubstituentMoleculeStereochemistryLigand (biochemistry)Binding siteBinding energyCrystallographyComputational chemistryThermodynamicsPhysical chemistryOrganic chemistryPhysicsNuclear physicsBiochemistryReceptorProtein Structure and DynamicsComputational Drug Discovery MethodsCrystallography and molecular interactions