MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma
Zehang Zhuang, Pei Yu, Nan Xie, Yue Wu, Haichao Liu, Ming Zhang, Yifan Tao, Weiwang Wang, Hanqi Yin, Bin Zou, Jinsong Hou, Xiqiang Liu, Jiong Li, Hongzhang Huang, Cheng Wang
Abstract
: miR-204-5p-SNAI2/SUZ12/HDAC1/STAT3 regulatory circuit has a critical role in maintaining aggressiveness of HNSCC, suggesting that miR-204-5p might serve as a promising therapeutic target for clinical intervention.
Topics & Concepts
microRNASuppressorHead and neck squamous-cell carcinomaCancer researchHead and neckBasal cellMedicineHead and neck cancerPathologyOncologyBiologyInternal medicineRadiation therapyCancerGeneSurgeryBiochemistryMicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseases