Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice
Chen‐Ju Lin, Yu‐Che Cheng, Hung-Chih Chen, Yu-Kai Chao, Martin W. Nicholson, Eric Yen, Timothy J. Kamp, Patrick C.H. Hsieh
Abstract
The gut microbiota is a potential therapeutic target for cardiac ECM remodeling and heart structural integrity. By establishing a healthy gut microbiome or replenishing the derived metabolites, we could improve cardiac health under dysbiosis after pressure-overload stress.
Topics & Concepts
Gut floraPressure overloadCardiac function curveFibrosisBiologyCardiac fibrosisPreloadHeart failureEndocrinologyInternal medicineImmunologyMedicineMuscle hypertrophyHemodynamicsCardiac hypertrophyGut microbiota and healthClostridium difficile and Clostridium perfringens researchCardiac Ischemia and Reperfusion