Systemic administration of polymersomal oncolytic peptide LTX-315 combining with CpG adjuvant and anti-PD-1 antibody boosts immunotherapy of melanoma
Yifeng Xia, Jingjing Wei, Songsong Zhao, Beibei Guo, Fenghua Meng, Bert Klumperman, Zhiyuan Zhong
Topics & Concepts
AdjuvantOncolytic virusSystemic administrationImmunotherapyMelanomaImmune systemImmunopotentiatorCancer researchCancer immunotherapyCD8MedicineCpG OligodeoxynucleotideAntibodySpleenImmunogenicityImmunologyChemistryBiologyIn vivoGeneBiochemistryBiotechnologyGene expressionDNA methylationImmunotherapy and Immune ResponsesCancer Research and TreatmentsRNA Interference and Gene Delivery