Heparanase-Induced Activation of AKT Stabilizes β-Catenin and Modulates Wnt/β-Catenin Signaling during Herpes Simplex Virus 1 Infection
Lulia Koujah, Krishnaraju Madavaraju, Alex M. Agelidis, Chandrashekhar D. Patil, Deepak Shukla
Abstract
Heparanase (HPSE) and β-catenin have independently been implicated in regulating key pathophysiological processes, including neovascularization, angiogenesis, and inflammation; however, the relationship between the two proteins has remained elusive thus far. For that reason, characterizing this relationship is crucial and can lead to the development of novel therapeutics. For HSV-1 specifically, current antivirals are not able to abolish the virus from the host, leaving patients susceptible to episodes of viral reactivation. Identifying a host-based intervention can provide a better alternative with enhanced efficacy and sustained relief.
Topics & Concepts
Downregulation and upregulationHeparanaseCell biologySignal transductionHerpes simplex virusPhosphorylationMediatorProtein kinase BRegulatorBiologyCell signalingChemistryViral replicationUbiquitinCancer researchNF-κBFunction (biology)CellVirusPI3K/AKT/mTOR pathwayProteoglycans and glycosaminoglycans researchHerpesvirus Infections and TreatmentsProtease and Inhibitor Mechanisms