Enabling Technologies in Carbohydrate Chemistry: Automated Glycan Assembly, Flow Chemistry and Data Science
Mei‐Huei Lin, Jakob B. Wolf, Eric T. Sletten, Dario Cambié, José Danglad‐Flores, Peter H. Seeberger
Abstract
The synthesis of defined oligosaccharides is a complex task. Several enabling technologies have been introduced in the last two decades to facilitate synthetic access to these valuable biomolecules. In this concept, we describe the technological solutions that have advanced glycochemistry using automated glycan assembly, flow chemistry and data science as examples. We highlight how the synergies between these different technologies can further advance the field, with progress toward the realization of a self-driving lab for glycan synthesis.
Topics & Concepts
GlycanChemistryFlow chemistryNanotechnologySynthetic biologyGlycomicsField (mathematics)Realization (probability)Computer scienceBiochemical engineeringData scienceComputational biologyEngineeringContinuous flowBiochemistryMaterials scienceBiologyGlycoproteinPure mathematicsMathematicsStatisticsCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchChemical Synthesis and Analysis