Spinal AMPA receptors: Amenable players in central sensitization for chronic pain therapy?
Olga Kopach, Nana Voitenko
Abstract
influx into the DH neurons, thereby amplifying neuronal hyperexcitability. The DH circuits become over-excitable and carry out aberrant sensory processing; this causes an increase in pain sensation in central sensory pathways, giving rise to chronic pain syndrome. Current knowledge of the contribution of spinal AMPAR to the cellular mechanisms relating to chronic pain provides opportunities for developing target-based therapies for chronic pain intervention.
Topics & Concepts
AMPA receptorNeuroscienceChronic painSpinal cordNociceptionSensory systemMedicineNeuropathic painSensitizationSynaptic plasticityGlutamate receptorReceptorPsychologyInternal medicinePain Mechanisms and TreatmentsIon channel regulation and functionNeuroscience and Neuropharmacology Research