Rhodium(<scp>i</scp>) N-heterocyclic carbene complexes: synthesis and cytotoxic properties
Ichraf Slimani, Serap Şahin‐Bölükbaşı, Mustafa Ulu, Enes Evren, Nevın Gürbüz, İlknur Özdemir, İlknur Özdemir, Naceur Hamdi, İsmaıl Özdemır, İsmaıl Özdemır
Abstract
A series of benzimidazolium salts and their [RhCl(NHC)(COD)] complexes were synthesized. All compounds were screened for<italic>in vitro</italic>cytotoxic activities against a panel of human cancer cells (HT-29 colon, Ishikawa endometrial, U-87 glioblastoma) using the MTT assay for 48 h incubation time.
Topics & Concepts
ChemistryCytotoxic T cellRhodiumCarbeneIn vitroMTT assayCytotoxicityStereochemistryIncubationBiochemistryCatalysisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods