Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms
Rohma Ghani, Benjamin H. Mullish, Julie A. K. McDonald, Anan Ghazy, Horace R. Williams, Eimear Brannigan, Siddharth Mookerjee, Giovanni Satta, Mark Gilchrist, Neill Duncan, Richard Corbett, Andrew J. Innes, Jiří Pavlů, Mark Thursz, Frances Davies, Julian R. Marchesi
Abstract
Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
Topics & Concepts
Fecal bacteriotherapyBacteremiaFecesMultiple drug resistanceTransplantationAntibioticsMedicineMicrobiologyBiologyInternal medicineClostridium difficileClostridium difficile and Clostridium perfringens researchMicroscopic ColitisGastrointestinal motility and disorders