The many faces of the anti-COVID immune response
Santosha A. Vardhana, Jedd D. Wolchok
Abstract
The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Immune systemAcquired immune systemCoronavirusOutbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakImmunityViral infectionInnate immune systemVirologyBiologyImmunologyMedicineVirusDiseaseInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesImmune Cell Function and Interaction