Adenovirus-α-Defensin Complexes Induce NLRP3-Associated Maturation of Human Phagocytes via Toll-Like Receptor 4 Engagement
Karsten Eichholz, Tuan Hiep Tran, Coraline Chéneau, Thi Thu Phuong Tran, Océane Paris, Martine Pugnière, Eric J. Kremer
Abstract
This study examines the interactions between danger-associated molecular patterns and human adenoviruses, and their impact on vaccines. HAdVs and HNP-1 can interact, and these interactions will modify the response of antigen-presenting cells, which will influence vaccine efficacy.
Topics & Concepts
BiologyReceptorToll-like receptorCell biologyDefensinImmunologyInnate immune systemTollInflammationBiochemistryPeptideAntimicrobial Peptides and ActivitiesImmune Response and InflammationImmunotherapy and Immune Responses