Mrc1<sup>+</sup> macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation <i>via</i> the AKT/Rb signaling pathway
Linxi Huang, Wei Chen, Zhuojing Tan, Yunxiao Huang, Xinji Gu, Lantian Liu, Hongxia Zhang, Yihan Shi, Jiarong Ding, Chengjian Zheng, Zhiyong Guo, Bing Yu
Abstract
macrophages attenuated crystal nephropathy through promoting renal tubule cell proliferation via the AKT/Rb signaling pathway. These findings could lead to the identification of potential therapeutic targets for the treatment of crystal nephropathy.
Topics & Concepts
Cell biologyPI3K/AKT/mTOR pathwayBiologyCellProtein kinase BCell growthChemistryKidneyMolecular biologySignal transductionEndocrinologyBiochemistryChronic Kidney Disease and DiabetesKidney Stones and Urolithiasis TreatmentsRenal and related cancers