mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
James Maksymetz, Nellie Byun, Deborah J. Luessen, Brianna Li, Robert Barry, John C. Gore, Colleen M. Niswender, Craig W. Lindsley, Max E. Joffe, P. Jeffrey Conn
Abstract
PAMs could reverse cortical GABAergic deficits and exhibit efficacy in treating cognitive dysfunction in schizophrenia.
Topics & Concepts
InterneuronLong-term potentiationNeuroscienceSchizophrenia (object-oriented programming)SomatostatinCognitionPsychologyBiologyMedicineInternal medicinePsychiatryInhibitory postsynaptic potentialReceptorNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionPhotoreceptor and optogenetics research