TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages
Ankita Dabla, Yi Chu Liang, Nusrah Rajabalee, Courtney Irwin, Carolyn G. J. Moonen, Jessie V. Willis, Stefania Berton, Jim Sun
Abstract
Mycobacterium tuberculosis is one of the most ancient bacterial pathogens and remains the leading cause of death from a single bacterial agent. The success of M. tuberculosis relies greatly on its ability to parasitize and disable its host macrophages.
Topics & Concepts
TREM2MacrophageImmune systemMycobacterium tuberculosisMicrobiologyBiologyTumor necrosis factor alphaIntracellular parasiteInterferonInterferon gammaImmunologyTuberculosisMedicineBiochemistryMyeloid cellsPathologyIn vitroInflammation biomarkers and pathwaysImmune Response and InflammationImmune cells in cancer