One‐Pot Synthesis of 5‐Amino‐1,2,3‐triazole Derivatives via Dipolar Azide−Nitrile Cycloaddition and Dimroth Rearrangement under Solvent‐Free Conditions
Pavel S. Gribanov, Edita M. Atoian, Anna N. Philippova, Maxim A. Topchiy, Andrey F. Asachenko, Sergey N. Osipov
Abstract
Abstract An efficient one‐pot methodology for the preparation of 5‐amino‐1,2,3‐triazole derivatives based on the combination of dipolar azide−nitrile cycloaddition with Dimroth rearrangement under solvent‐free conditions has been developed.
Topics & Concepts
NitrileChemistryCycloadditionAzide1,3-Dipolar cycloadditionSolventTriazoleOrganic chemistry1,2,3-TriazoleCombinatorial chemistryCatalysisClick Chemistry and ApplicationsSynthesis and Biological EvaluationChemical Synthesis and Analysis