Targeting β-catenin and PD-L1 simultaneously by a racemic supramolecular peptide for the potent immunotherapy of hepatocellular carcinoma
Zheng‐Jun Zhou, Xiao Li, Guang Yang, Jingmei Wang, Baohua Li, Yinong Huang, Jin Yan, Kaishan Tao
Abstract
The successful implementation of this strategy could revitalize ICIs blockage therapy and promote the discovery of artificial peptides for HCC immunotherapy.
Topics & Concepts
ImmunotherapyCancer researchHepatocellular carcinomaWnt signaling pathwayImmune checkpointIn vivoPeptideCD8ChemistryImmune systemMedicinePharmacologySignal transductionImmunologyBiologyBiochemistryBiotechnologyImmunotherapy and Immune ResponsesPeptidase Inhibition and AnalysisCancer Immunotherapy and Biomarkers