SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
Kathleen Klotz‐Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Pamela Riemer, Mareen Lüthen, Thomas Sell, Katharina Kasack, Bastian Gastl, Sylvia Ispasanie, Tincy Simon, Nicole Janssen, Matthias Schwab, Johannes Zuber, David Horst, Nils Blüthgen, Reinhold Schäfer, Markus Morkel, Christine Sers
Abstract
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Topics & Concepts
Synthetic lethalityCancer researchApoptosisDNA damageColorectal cancerBiologySmall hairpin RNACell biologyMutantKinaseDNA replicationDNA repairNuclear proteinCancerTranscription factorGene knockdownGeneGeneticsDNADNA Repair MechanismsMicrotubule and mitosis dynamicsCancer-related Molecular Pathways