Tandem Synthesis of 2-Carboxybenzofurans <i>via</i> Sequential Cu-Catalyzed C–O Coupling and Mo(CO)<sub>6</sub>-Mediated Carbonylation Reactions
Qinliang Mo, Nan Sun, Liqun Jin, Baoxiang Hu, Zhenlu Shen, Xinquan Hu
Abstract
A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C–O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.
Topics & Concepts
ChemistryCarbonylationTandemIntramolecular forceCatalysisIntermolecular forceBenzofuranCombinatorial chemistryCoupling reactionStereochemistryOrganic chemistryMedicinal chemistryCarbon monoxideMoleculeMaterials scienceComposite materialCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms