Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
Qi Li, Zhen Wang, Vy M. Dong, Xiao‐Hui Yang
Abstract
As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
Topics & Concepts
ChemistryEnantioselective synthesisReagentAllylic rearrangementCatalysisMethanolCombinatorial chemistryOrganic chemistryAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis