Hypoglycemic and Hypolipidemic Effects of Malonyl Ginsenosides from American Ginseng (<i>Panax quinquefolius</i> L.) on Type 2 Diabetic Mice
Zhi Liu, Chun-Yuan Qu, Jiaxin Li, Yanfang Wang, Wei Li, Chong‐Zhi Wang, Dongsheng Wang, Jia Song, Guangzhi Sun, Chun‐Su Yuan
Abstract
, and GLUT4 in the liver and skeletal muscle were significantly upregulated after PQ-MGR treatment. In contrast, the protein expressions of p-IRS1 and p-JNK were significantly downregulated. Our results revealed that PQ-MGR could ameliorate glucose and lipid metabolism and insulin resistance in T2DM via regulation of the insulin receptor substrate-1/phosphoinositide3-kinase/protein-kinase B (IRS1/PI3K/Akt) and AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC) pathways. These findings suggest that PQ-MGR may be used as an antidiabetic candidate drug for T2DM treatment.
Topics & Concepts
GinsengAspartate transaminaseIRS1ChemistryInsulin resistanceGLUT4American ginsengProtein kinase BAlanine transaminaseStreptozotocinEndocrinologyGinsenosideInternal medicineTriglycerideInsulinPharmacologyInsulin receptorDiabetes mellitusCholesterolMedicineBiochemistryApoptosisAlkaline phosphataseEnzymePathologyAlternative medicineGinseng Biological Effects and ApplicationsPharmacological Effects of Natural CompoundsLipid metabolism and disorders