An unusual<i>trans</i>-hydrosilylation of prochiral 1,1-disubstituted cyclopropenes revealing the different nature of asymmetric palladium and rhodium catalysis
Han-Qi Zhou, Fang‐Ying Ling, Xiao‐Jun Fang, Hua‐Jie Zhu, Li Li, Fei Ye, Zheng Xu, Li‐Wen Xu
Abstract
A highly enantioselective palladium-catalyzed hydrosilylation reaction of prochiral 1,1-disubstituted cyclopropenes to access a wide variety of silylcyclopropanes bearing a quaternary carbon-stereocenter with good diastereo- and enantioselectivities.
Topics & Concepts
HydrosilylationStereocenterChemistryEnantioselective synthesisPalladiumRhodiumCatalysisQuaternary carbonOrganic chemistryMedicinal chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions