Design, synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual inhibitors
Qinsheng Sun, Qiuzi Dai, Cunlong Zhang, Yan Chen, Lei Zhao, Zigao Yuan, Yuyang Jiang
Topics & Concepts
ChemistryHydroxamic acidHDAC1Histone deacetylaseDNA methyltransferaseAcetylationEpigeneticsMethyltransferaseNucleosideHistoneBiochemistryMethylationDNAStereochemistryGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationAdenosine and Purinergic Signaling