Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells
Mikkel Elle Lepperød, Ane Charlotte Christensen, Kristian Kinden Lensjø, Alessio Paolo Buccino, Jai Y. Yu, Marianne Fyhn, Torkel Hafting
Abstract
) cells in the MSA enabled selective pacing of local field potential (LFP) oscillations in MEC. During optogenetic stimulation, the grid cells were locked to the imposed pacing frequency but kept their spatial patterns. Phase precession was abolished, and speed information was no longer reflected in the LFP oscillations but was still carried by rate coding of individual MEC neurons. Together, these results support that theta oscillations are not critical to the spatial pattern of grid cells and do not carry a crucial velocity signal.
Topics & Concepts
OptogeneticsParvalbuminGrid cellNeurosciencePrecessionPhysicsAnatomyGridBiologyGeologyGeodesyAstronomyPhotoreceptor and optogenetics researchNeural dynamics and brain functionCircadian rhythm and melatonin