Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery
Xinhao Fang, Kai Gao, Jianxiang Huang, Kexin Liu, Linying Chen, Ying Piao, Xiangrui Liu, Jianbin Tang, Youqing Shen, Zhuxian Zhou
Abstract
H NMR spectroscopy. The interior functionalized peptide dendrimers improved the encapsulation capability of SN38 and sustained the release profiles. Enhanced molecular interactions between the peptide dendrimers and drugs were explored by both NMR experiments and computer simulations. The peptide dendrimer/SN38 formulations showed potent antitumor activity against multiple cancer cell lines. We believe that this strategy can be applied to the synthesis of tailor-made functional peptide dendrimers for drug-specific delivery and other diverse biomedical applications.
Topics & Concepts
DendrimerPeptidePolylysineCombinatorial chemistryDrug deliveryMaterials scienceNanotechnologyMolecular massAmino acidDrugBiophysicsChemistryBiochemistryPolymer chemistryBiologyPharmacologyEnzymeDendrimers and Hyperbranched PolymersRNA Interference and Gene DeliveryChemical Synthesis and Analysis