What is the optimal loading dose of broad-spectrum β-lactam antibiotics in septic patients? Results from pharmacokinetic simulation modelling
Isabelle Delattre, Maya Hites, Pierre‐François Laterre, Thierry Dugernier, Herbert Spapen, Pierre Wallemacq, Frédérique Jacobs, Fabio Silvio Taccone
Topics & Concepts
CefepimeMeropenemPharmacokineticsCeftazidimePiperacillinPharmacodynamicsSeptic shockMedicineAntibioticsMinimum inhibitory concentrationPharmacologyDosingLoading doseBroad spectrumSepsisPseudomonas aeruginosaAnesthesiaChemistryInternal medicineMicrobiologyBiologyAntibiotic resistanceGeneticsCombinatorial chemistryBacteriaAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory InfectionsAntibiotic Use and Resistance